1-(Ethanesulfonyl)piperazine → HCID 11679107, compound

HRID 1367714Notes

Reaction equation

HRID 1367714 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1.[CH2:35]([S:37]([N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)(=[O:39])=[O:38])[CH3:36]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:43]3[CH2:42][CH2:41][N:40]([S:37]([CH2:35][CH3:36])(=[O:38])=[O:39])[CH2:45][CH2:44]3)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 4152941-(Ethanesulfonyl)piperazineHCID 60057215HCID 60057215, compound

Product 1

HCID 11679107HCID 11679107, compound

Procedure

[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-ethanesulfonyl-piperazin-1-yl)-methanone was prepared from (4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 6) and 1-ethanesulfonyl-piperazine (prepared from 1-tert-butyloxycarbonyl-piperazine and ethanesulfonyl chloride) in an analogous manner as described in example 8. LR-MS: 659.2 [(M+H)+].

Sources & evidence

ORD record
ord-1c8fa6efb4e940be8b618ec5b4984d79
Source dataset
uspto-grants-2011_02
Patent number
US07893278B2

Reaction notes

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