関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 18-(p-Iodophenyl)octadecanol | HCID 11655804 | — |
| 反応物 | Ethyl 17-hydroxy-heptadecanoate | HCID 21833404 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 86625642 | HCID 86625642 | 90% |
反応手順
Ethyl 17-hydroxy-heptadecanoate 79 (264 mg, 0.84 mmol), Ph3P (262 mg, 1 mmol) and imidazole (94 mg, 1.39 mmol) were dissolved in the mixture of CH2Cl2 (3 ml) and benzene (3 ml) and cooled to 0° C. Solid 12 (254 mg, 1 mmol) was added and the reaction mixture was stirred at 0° C. for 40 min. The reaction mixture was quenched by addition of MeOH (0.5 ml), diluted with EtOAc and washed with the aqueous NaHCO3—Na2S2O3 solution, dried over Na2SO4 and evaporated. Chromatography in hexane-EtOAc (97:3) afforded the product 80 (321 mg, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07893286B2 |
|---|
| 出典データセット | uspto-grants-2011_02 |
|---|
| ORD ID | ord-4b8fe358cf8f479d9f84c425e6d4116d |
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| 出典メモ | uspto-grants-2011_02 |
|---|
