Diethyl (cyanomethyl)phosphonate → HCID 66959138, compound

Participants

Reaction Steps

The reaction was carried out as described in procedure C using silyl ether 12 (1 g, 2.6 mmol) and diethyl(cyanomethyl)phosphonate (691 mg, 631 μl, 3.9 mmol). Flash column chromatography (SiO2 hexane:ethyl acetate 20:1) afforded the two isomers 24 as a colourless oil (641 mg, 1.47 mmol, 57%). m/z (FAB) 435.3 (M+, 100%); HRMS (FAB+) calcd for C28H41ONSi 435.2957, found 435.2961.

Provenance & Evidence