HCID 66959976, compound → HCID 66960256, compound

Participants

Reaction Steps

A stirred, degassed, solution of ether 46 (200 mg, 0.36 mmol) in THF (10 mL) was treated with 10% Pd/C (20 mg) and placed under an atmosphere of hydrogen overnight. The reaction was then filtered through celite and evaporated to give the desired phenol 47 as a clear colourless oil δH 6.80 (1H, s, ArH), 6.65 (1H, s, ArH), 5.55 (1H, s, OH), 3.87 (3H, s, OMe), 3.52-3.82 (4H, m, 2×OCH2), 3.42-3.48 (1H, m, 17-CH), 2.72-2.84 (2H, m, 6-CH2), 1.20-2.36 (13H, m), 0.94 (9H, s, tBu), 0.89 (3H, s, 18-Me) and 0.12 (6H, s, SiMe2).

Provenance & Evidence