Acetic Acid → HCID 86613018, compound

HRID 1367750Notes

Reaction equation

HRID 1367750 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([OH:24])(=[O:23])[CH3:22]>CCCCCC>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([O-:24])(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 68617Sertraline

Product 1

HCID 86613018HCID 86613018, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

71 gms of sertraline base is dissolved in 350 ml of n-hexane under stirring at room temperature. 14 ml acetic acid is added to the clear solution and stirred for 10 minutes at 25° C. and refluxed at 60° C. for 30 minutes to obtain a thick white precipitate. The precipitated solid is filtered. The product is dried in a fluid bed dryer at 60° C. for 3-4 hours to give sertraline acetate.

Workup

  1. stirringstirred for 10 minutes at 25° C.
  2. temperaturerefluxed at 60° C. for 30 minutes
  3. customto obtain a thick white precipitate
  4. filtrationThe precipitated solid is filtered
  5. customThe product is dried in a fluid bed dryer at 60° C. for 3-4 hours

Sources & evidence

ORD record
ord-2dc818a45a824595bbd7db0f5d814b4e
Source dataset
uspto-grants-2011_02
Patent number
US07893300B2

Reaction notes

Loading…