反应详情

71 gms of sertraline base is dissolved in 350 ml of n-hexane under stirring at room temperature. 14 ml acetic acid is added to the clear solution and stirred for 10 minutes at 25° C. and refluxed at 60° C. for 30 minutes to obtain a thick white precipitate. The precipitated solid is filtered. The product is dried in a fluid bed dryer at 60° C. for 3-4 hours to give sertraline acetate.

1. stirringstirred for 10 minutes at 25° C.
2. temperaturerefluxed at 60° C. for 30 minutes
3. customto obtain a thick white precipitate
4. filtrationThe precipitated solid is filtered
5. customThe product is dried in a fluid bed dryer at 60° C. for 3-4 hours