Water → HCID 11706662, compound

Participants

Reaction Steps

N-(1-cyanocyclopropyl)-2(R)-[2,2,2-trifluoro-1(S)-(4-fluorophenyl)ethylamino]-3-(4-trifluoromethyl-pyridin-3-ylmethylsulfanyl)-propionamide was dissolved in CH3OH (10 mL) and an aqueous solution of Oxone® (3 g in 10 mL H2O, 10 mmol) was added. The reaction mixture was stirred at room temperature 3 h. Solvent was removed under the reduced pressure. The aqueous layer was extracted with ethyl acetate. The organic layer was washed with brine and dried with MgSO4. The solvent was removed under the reduced pressure and the crude product was purified by prep-HPLC to isolate the title compound from the diastereomeric mixture.

Provenance & Evidence