4-(3-Chloro-2-fluoro-phenyl)-1,3-dihydro-indol-2-one → 2-[4-(3-Chloro-2-fluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 136786Notes

Reaction equation

HRID 136786 reaction equation
[CH3:1][c:2]1[c:3]([CH:20]=[O:21])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2.[Cl:22][c:23]1[c:24]([F:39])[c:25](-[c:29]2[c:30]3[c:34]([cH:35][cH:36][cH:37]2)[NH:33][C:32](=[O:38])[CH2:31]3)[cH:26][cH:27][cH:28]1>>[CH3:1][c:2]1[c:3]([CH:20]=[C:31]2[c:30]3[c:29](-[c:25]4[c:24]([F:39])[c:23]([Cl:22])[cH:28][cH:27][cH:26]4)[cH:37][cH:36][cH:35][c:34]3[NH:33][C:32]2=[O:38])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 666072894-(3-Chloro-2-fluoro-phenyl)-1,3-dihydro-indol-2-oneHCID 866376773-methyl-4-oxo-5-(2-piperidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 666071282-[4-(3-Chloro-2-fluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-2671fd56015f4673b526e0e40b8f31a0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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