HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-phenylalaninate hydrochloride → 1-Methylisoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | 1-(2-Methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid | HCID 66940461 | — |
| Product | 1-Methylisoquinoline-3-carboxylic acid | HCID 18965010 | 11% |
Reaction Steps
0.25 g (11% overall yield) of 1-methyl-isoquinoline-3-carboxylic acid was synthesized according to the procedure described for the synthesis of 1-(2-methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid (in Example 298) starting from 2.20 g (10 mmol) of phenylalanine methyl ester hydrochloride. LCMS: 188 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893267B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-4af1d344cfc646af9a7c6393c1f7ed01 |
| Source note | uspto-grants-2011_02 |