methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate → HCID 66940377, compound

HRID 1367936Notes

Reaction equation

HRID 1367936 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([NH2:14])[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].CO[C:17](=O)[C:18]1C=C(C)C=C([N+]([O-])=O)[C:19]=1N>>[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([NH2:14])[NH:10][C:9]=2[CH:8]=[C:7]([CH2:17][CH2:18][CH3:19])[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 24730367methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate2×HCID 58213211Methyl 2-amino-5-methyl-3-nitrobenzoate

Product 1

HCID 66940377HCID 66940377, compoundYield 85%

Procedure

0.3 g (85% overall yield) 2-amino-6-propyl-1H-benzoimidazole-4-carboxylic acid methyl ester was synthesized according to procedures described for the synthesis of 2-Amino-1H-benzoimidazole-4-carboxylic acid methyl ester (intermediate A) starting from 0.35 g (1.5 mmol) of above synthesized 2-amino-5-methyl-3-nitrobenzoic acid methyl ester. LCMS: 234 (M+1)+.

Sources & evidence

ORD record
ord-ad83016b508a4cbd8605074da6725848
Source dataset
uspto-grants-2011_02
Patent number
US07893267B2

Reaction notes

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