HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1367948Generated: October 30, 2026
Water → Methyl 3-amino-5-fluoro-2-nitrobenzoate
https://huagongshe.com/reaction/1367948
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | Methyl 3,5-difluoro-2-nitrobenzoate | HCID 46311132 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-amino-5-fluoro-2-nitrobenzoate | HCID 58724451 | — |
Reaction Steps
6.0 g (27.5 mmol) of 3,5-difluoro-2-nitro-benzoic acid methyl ester was dissolved in DMF and treated with 2.9 g (30.25 mmol) of ammonium carbonate. The reaction was heated at 60° C. for 6 h. Water was added to the reaction mixture. The solid produced was collected by filtration and washed with water to produce 3-amino-5-fluoro-2-nitro-benzoic acid methyl ester. LCMS: 215 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07893267B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-c78256e96a1848c480b9a0fa42676f96 |
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| Source note | uspto-grants-2011_02 |
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