反应详情

温度

-20 °C

5.4 g (20 mmol) of 5-bromo-4-chloroisatoic anhydride was suspended in 20 ml of conc. H2SO4 at −10° C. and cooled to −20° C. 2.1 g (21 mmol) of potassium nitrate was dissolved in 6 mL of sulfuric acid and cooled to 0° C., was then added dropwise to the reaction mixture. The reaction mixture was then stirred 10° C. for 15 min and warmed to room temperature overnight. The mixture was poured in to a beaker containing ice. The resulting solid was collected by filtration, washed with cold water and dried to produce 3.2 g (50%) of 5-bromo-4-chloro-3-nitroisatoic anhydride. LCMS: 323 (M+1)+.

1. temperaturecooled to 0° C.
2. additionwas then added dropwise to the reaction mixture
3. temperaturewarmed to room temperature overnight
4. additionThe mixture was poured in to a beaker
5. additioncontaining ice
6. filtrationThe resulting solid was collected by filtration
7. washwashed with cold water
8. customdried