HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylate → HCID 11096910, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylate | HCID 5301401 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | HCID 70182102 | HCID 70182102 | — |
| Product | HCID 11096910 | HCID 11096910 | 26% |
Reaction Steps
1.8 g (6.26 mmol) of 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester and 3.3 g (37.6 mmol) of MnO2 in toluene/dioxane/THF was heated under reflux overnight. After gravity filtration, the hot filtrate was evaporated to produce 0.4 g (1.62 mmol, 26%) of 6,7-dimethoxy-isoquinoline-3-carboxylic acid methyl ester. LCMS: 248 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893267B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-7bdf2be94a2b4e1197c0b5f61e53e711 |
| Source note | uspto-grants-2011_02 |