Nitric Acid → HCID 18929901, compound

HRID 1367974Notes

Reaction equation

HRID 1367974 reaction equation
[N+:1]([O-:4])(O)=[O:2].OS(O)(=O)=O.[F:10][C:11]1[CH:12]=[C:13]([CH:17]=[C:18]([F:21])[C:19]=1[F:20])[C:14]([OH:16])=[O:15]>>[N+:1]([C:17]1[C:18]([F:21])=[C:19]([F:20])[C:11]([F:10])=[CH:12][C:13]=1[C:14]([OH:16])=[O:15])([O-:4])=[O:2]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 8531543,4,5-Trifluorobenzoic acid

Product 1

HCID 18929901HCID 18929901, compoundYield 80%

Procedure

5.0 mL of conc. HNO3 at 0° C. was slowly treated with 10.0 mL of conc. H2SO4, then 3.52 g (20.0 mmol) of 3,4,5-trifluoro-benzoic acid. The reaction mixture was warmed up to room temperature and stirred overnight. The mixture was poured into a beaker containing ice. The resulting solid was collected by filtration, washed with cold water and dried to produce 3.4 g (16.0 mmol, 80%) of 2-nitro-3,4,5-trifluoro-benzoic acid. LCMS: 222 (M+1)+.

Workup

  1. additionThe mixture was poured into a beaker
  2. additioncontaining ice
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with cold water
  5. customdried

Sources & evidence

ORD record
ord-c88801faf44a4e639a29fe38de7261f2
Source dataset
uspto-grants-2011_02
Patent number
US07893267B2

Reaction notes

Loading…