HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → HCID 178466833, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate | HCID 24730367 | — |
| Reactant | HCID 86608396 | HCID 86608396 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178466833 | HCID 178466833 | — |
Reaction Steps
0.8 g (3.7 mmol) of 2,3-diamino-5-ethoxy-4-fluoro-benzoic acid was subjected to a similar cyclization condition as illustrated in intermediate A by using 1.2 g (11.2 mmol) of BrCN in methanol to produce 2-amino-6-ethoxy-7-fluoro-1H-benzoimidazole-4-carboxylic acid. LCMS: 240 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893267B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-750f097f258f4d98a30ef02cbb94435b |
| Source note | uspto-grants-2011_02 |