HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Amino-5-fluoro-2-nitro-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | Ethyl 3,5-difluoro-2-nitrobenzoate | HCID 46311351 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Amino-5-fluoro-2-nitro-benzoic acid ethyl ester | HCID 66940524 | 75% |
Reaction Steps
4.64 g (20 mmol) of 3,5-difluoro-2-nitro-benzoic acid ethyl ester in DMF and 2.1 g (22 mmol) of ammonium carbonate was heated at 60° C. for 6 h. The reaction mixture was treated with water. The resulting solid was collected by filtration and washed with water to produce 3.4 g (15.0 mmol, 75%) of 3-amino-5-fluoro-2-nitro-benzoic acid ethyl ester. LCMS: 229 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893267B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-487e0cf9e336447cafce0549498d7d66 |
| Source note | uspto-grants-2011_02 |