Sodium Bicarbonate → HCID 18519616, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (0.43 g), methyl 4-bromocrotonate (0.22 g ) and sodium bicarbonate (0.3 g ) in methanol was stirred at 25° C. for 12 hours . The solvent was removed under reduced pressure and ethyl acetate (200 ml) was added. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to an oil. The crude product was purified by column chromatography on silica gel using ethyl acetate-hexane (1:2) as eluent to give title compounds (0.097 g)

Provenance & Evidence