Potassium Carbonate → HCID 18519614, compound

Participants

Reaction Steps

A mixture of 3-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-1-methyl-6-trifluromethyl-2,4(1H,3H)-pyrimidinedione (1.07 g), ethyl bromopropionate (0.61 g) and potassium carbonate (0.414 g) in acetonitrile (30 ml) was stirred at room temperature overnight. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and evaporated to give an amorphous (0.95 g). The amorphous was purified on a silica gel column, eluted with methylene chloride-ethyl acetate (19:1 and 9:1) to give the title compound (0.86 g) as white crystals.

Provenance & Evidence