HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dibromoethane → HCID 18519623, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-methyl-6-trifluoromethyl-3-(6-amino4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione | HCID 12056912 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 18519623 | HCID 18519623 | 6.5% |
Reaction Steps
A mixture of 3-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-primidinedione (0.4 g), 1,2-dibromoethane (0.26 g) and potassium carbonate (0.312 g) in acetone (30 ml) was heated at reflux for 6 hours. The insoluble precipitate was removed through Celite and the filtrate was concentrated to an oil. The oily substance was purified by column chromatography on silica gel using ethyl acetate-hexane (1:2) as eluent to give the title compounds (0.028 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06573218B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-0c0cb557b6bf438cab87d722c1c1d921 |
| Source note | uspto-grants-2003_06 |