Water → HCID 70011121, compound

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Reaction Steps

A mixture of 2-(2-amino-4-chloro-6-fluoro-3-methoxyphenyl)-5-trifluoromethylpyridazin-3-one (0.39 g) and borontribromide-methyl sulfide complex (1.8 g) in dichloroethane was heated at reflux temperature for 1 hour under nitrogen atmosphere. The mixture was poured into water and extracted with methylene dichloride. The organic phase was dried over anhydrous sodium sulfate and concentrated to give the title compound. 1H NMR (CDCl3, 300 MHz) 4.61 (3H, br s), 6.55 (1H, d, J=9.4 Hz), 7.30 (1H, m), 8.05 (1H, d, J=2.2 Hz) ppm.

Provenance & Evidence