HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Cvt-2738
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chloro-N-(2,6-dimethylphenyl)acetamide | HCID 70798 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Cvt-2738 | HCID 2608606 | — |
Reaction Steps
To a solution of compound 3 (5 g, 25.2 mmol) in ethanol (100 mL) was added piperazine 4 (2.1 g, 25.0 mmol) and N,N-diisopropylethylamine (3.2 g, 25.2 mmol). The reaction mixture was refluxed for 24 h. The mixture was concentrated in vacuo and the residue was purified by column chromatography (10:1 DCM: MeOH) to afford compound 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06573264B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-71c178076df2433e87dcdf606395f5a7 |
| Source note | uspto-grants-2003_06 |