Phenyl isocyanate → HCID 10407969, compound

HRID 1368133Notes

Reaction equation

HRID 1368133 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:18]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[C:10]([NH2:19])[C:9]=2[N:8]=[C:7]1[CH3:20].[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[NH2:19][C:10]1[C:9]2[N:8]=[C:7]([CH3:20])[N:6]([CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:28]([NH:27][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:29])[C:18]=2[C:17]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:11]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 22344425HCID 22344425, compound

Product 1

HCID 10407969HCID 10407969, compound

Procedure

Using the general method of Example 143, 1-(4-aminobutyl)-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine (500 mg, 1.9 mmol) was reacted with phenyl isocyanate to provide 123 mg of N-[4-(4-amino-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-N′-phenylurea as a light brown solid, m.p. 171.5-172.5° C. Analysis: Calculated for C22H24N6O.0.60 H2O: %C 66.18; %H, 6.36; %N, 21.05; Found: %C, 66.05; %H, 6.43; %N, 20.61.

Sources & evidence

ORD record
ord-04edbc66454945788809c01955a2b793
Source dataset
uspto-grants-2003_06
Patent number
US06573273B1

Reaction notes

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