Sulfuric acid magnesium salt (1:1) → 1-(4-Methoxyphenyl)-3,4-dihydronaphthalen-2(1H)-one

HRID 13682Notes

Reaction equation

S([O-])([O-])(=O)=O.[Mg+2].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]23[O:25][CH:16]2[CH2:17][CH2:18][C:19]2[C:24]3=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18][CH2:17][C:16]2=[O:25])=[CH:13][CH:14]=1

Participants

Conditions

Temperature: 80 °C

Procedure

6.0 Grams (0.05 mols) of magnesium sulfate and 500 mL of toluene were added to 50.5 g (0.20 mols) of 7b-(4-methoxyphenyl)-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a]naphthalene, and the mixture was heated at 80° C. for 2 hours. After cooled, the reaction product was washed two times each with 250 mL of water, and the organic layer was condensed under reduced pressure to obtain 1-(4-methoxyphenyl)-3,4-dihydro-1H-naphthalene-2-one represented by the following formula,

Workup

temperatureAfter cooled
washthe reaction product was washed two times each with 250 mL of water
customcondensed under reduced pressure

Sources & evidence

ORD record: ord-c9b12048bd9b4888b1f44d2569dd30f8
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728154B2

Reaction notes

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