反应详情

Acetic anhydride (430 mg) and pyridine (416 mg) were added to a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine, dried over magnesium sulfate, and concentrated to dryness under reduced pressure to give 4-acetoxy-2-chlorotoluene as a pale-yellow oil (645 mg).

1. washThe reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated to dryness under reduced pressure