反应详情

温度

65 °C

To a suspension of 2-amino-6-bromo-3-nitropyridine (23.9 g) in acetic acid (48 ml) were added acetic anhydride (48 ml) and sulfuric acid (2.9 ml), and the mixture was heated at 65° C. for 40 min. The reaction mixture once became homogeneous and a product soon precipitated to give a suspension. The reaction mixture was allowed to cool and poured into cold water (480 ml), which was followed by stirring for 30 min. The precipitate was collected by filtration and washed with water to give a crude product. This was suspended in ether (60 ml) and collected by filtration to give 2-(acetamido)-6-bromo-3-nitropyridine as a pale-yellow powder (27.2 g).

1. customThe reaction mixture once became homogeneous and a product soon precipitated
2. customto give a suspension
3. temperatureto cool
4. filtrationThe precipitate was collected by filtration
5. washwashed with water
6. customto give a crude product
7. filtrationcollected by filtration