Water → HCID 18520204, compound

Participants

Reaction Steps

3.0 g of 2-chlorobenzenesulfonamide, 2.0 g of thiocresol and 6.5 g of K2CO3 are stirred at 100° C. for 6 h in 30 ml of DMF and then at 120° C. for 13 h. The reaction mixture is poured onto 200 ml of water and extracted with 500 ml of EA. The organic phase is then washed with 100 ml of a saturated aqueous Na2CO3 solution. It is dried over MgSO4 and the solvent is removed in vacuo. Chromatography on silica gel using DIP yields 1.4 g of white crystals, m.p. 122-124° C.

Provenance & Evidence