Potassium Carbonate → HCID 59069401, compound

Participants

Reaction Conditions

Reaction Steps

A 50 mL round bottom flask equipped with a magnetic stir bar, nitrogen gas inlet, and thermocouple was charged with (2S,3S)-2-(4-bromophenyl)-3-methyloxiran-2-yl acetate (490 mg, 1.81 mmol) and methanol (20 mL), and the reaction mixture was cooled to 0° C. in an ice/water bath. Potassium carbonate (15 mg, 0.1 mmol) was added, and the mixture was stirred at 0° C. for 3 hours. The reaction mixture was concentrated and purified by column chromatography to give the product as an oil (208 mg, 50%): 1H NMR (CDCl3) δ 7.79 (d, 2H, J=8.4 Hz), 7.65 (d, 2H, J=8.8 Hz), 5.10 (q, 1H, J=7.0 Hz), 3.73 (bs, 1H), 1.44 (d, 3H, J=7.0Hz).

Provenance & Evidence