反应详情

温度

0 °C

1.00 g (4.45 mmol) of methyl 2-acetyl-5-phenylpentanoate is dissolved in 10 ml of dioxane and cooled to 0° C. 8.5 ml of a 1 M sodium hydroxide solution are added with cooling. After a reaction time of 5 h, the batch is concentrated, treated with 10 ml of ethyl acetate and 10 ml of water and extracted by shaking. The water phase is recovered, cooled to 0° C. and slowly treated with 1 N hydrochloric acid with cooling until pH 1 is reached. It is then extracted with dichloromethane. The dichloromethane phase is dried and directly reacted further without concentrating.

1. temperaturewith cooling
2. concentrationAfter a reaction time of 5 h, the batch is concentrated
3. additiontreated with 10 ml of ethyl acetate and 10 ml of water
4. extractionextracted
5. customThe water phase is recovered
6. temperaturecooled to 0° C.
7. additionslowly treated with 1 N hydrochloric acid
8. temperaturewith cooling until pH 1
9. extractionIt is then extracted with dichloromethane
10. dry with materialThe dichloromethane phase is dried
11. customdirectly reacted further
12. concentrationwithout concentrating