Potassium Hydroxide → 2-Acetyl-5-cyclohexylpentanoic acid

HRID 1368297Notes

Reaction equation

HRID 1368297 reaction equation
[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:5]([O:7]C)=[O:6])(=[O:3])[CH3:2].[OH-].[K+]>ClCCl>[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)[C:5]([OH:7])=[O:6])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18519791Methyl 2-acetyl-5-cyclohexylpentanoate

Product 1

HCID 183708122-Acetyl-5-cyclohexylpentanoic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Analogously to Example 29A, 450 mg (2.08 mmol) of methyl 2-acetyl-5-cyclo-hexylpentanoate are reacted with 1.5 ml of a 3.5 M potassium hydroxide solution in dichloromethane to give 2-acetyl-5-cyclohexylpentanoic acid.

Sources & evidence

ORD record
ord-d8204571504d42088b42075eeb489570
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

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