Potassium Hydroxide → 2-Acetyl-2-methyl-5-phenylpentanoic acid

HRID 1368298Notes

Reaction equation

[C:1]([C:4]([CH3:18])([CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([O:7]C)=[O:6])(=[O:3])[CH3:2].[OH-].[K+]>>[C:1]([C:4]([CH3:18])([CH2:9][CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:5]([OH:7])=[O:6])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 18519790Methyl 2-acetyl-2-methyl-5-phenylpentanoate

Product 1

HCID 185197972-Acetyl-2-methyl-5-phenylpentanoic acid

Procedure

Analogously to Example 29A, 4.90 g (18.7 mmol) of methyl 2-acetyl-2-methyl-5-phenylpentanoate are reacted with 10.0 ml of a 3.5 M potassium hydroxide solution to give 2-acetyl-2-methyl-5-phenylpentanoic acid.

Sources & evidence

ORD record: ord-15ad14cdd4414a8794bcb4db6dfad8e2
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573263B2

Reaction notes

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