Sulfuric acid magnesium salt (1:1) → 1-benzo[1,3]dioxole-5-yl-3,4-dihydro-1H-naphthalene-2-one

HRID 13683Notes

Reaction equation

S([O-])([O-])(=O)=O.[Mg+2].[O:7]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]34[O:26][CH:17]3[CH2:18][CH2:19][C:20]3[CH:21]=[CH:22][CH2:23][CH2:24][C:25]=34)=[CH:15][C:10]=2[O:9][CH2:8]1>C1(C)C=CC=CC=1>[O:7]1[C:11]2[CH:12]=[CH:13][C:14]([CH:16]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:17]3=[O:26])=[CH:15][C:10]=2[O:9][CH2:8]1

Participants

Conditions

Temperature: 80 °C

Procedure

6.0 Grams (0.05 mols) of magnesium sulfate and 500 mL of toluene were added to 53.3 g (0.20 mols) of 7b-benzo[1,3]dioxole-5-yl-1a,2,3,7-tetrahydro-1-oxacyclopropa[a]naphthalene, and the mixture was heated at 80° C. for 2 hours. After cooled, the reaction product was washed two times each with 250 mL of water, and the organic layer was condensed under reduced pressure to obtain 1-benzo[1,3]dioxole-5-yl-3,4-dihydro-1H-naphthalene-2-one represented by the following formula,

Workup

temperatureAfter cooled
washthe reaction product was washed two times each with 250 mL of water
customcondensed under reduced pressure

Sources & evidence

ORD record: ord-ca196877dbe24d94a02195d86cd8d317
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728154B2

Reaction notes

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