4-Methylmorpholine → N-(1-{3-[(3,4-Dimethoxyphenyl)methyl]-5-oxo-2,5-dihydro-1,2,4-triazin-6-yl}ethyl)-2-(1-hydroxyethyl)-5-phenylpentanamide

Participants

Reaction Steps

1.01 g (4.55 mmol) of 2-(1-hydroxyethyl)-5-phenylpentanoic acid are reacted analogously to Example 39A with 0.67 g (4.96 mmol) of 1-hydroxy-1H-benzotriazole, 1.05 g (10.3 mmol) of 4-methylmorpholine, 0.95 g (4.96 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 1.20 g (4.13 mmol) of 6-(1-aminoethyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one to give 2-(1-hydroxyethyl)-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-tri azin-6-yl]-ethyl)}5-phenylpentanamide.

Provenance & Evidence