Dimethyl Sulfoxide → HCID 135824727, compound

Participants

Reaction Steps

Analogously to Example 40A, 320 mg (2.50 mmol) of oxalyl chloride, 390 mg (5.00 mmol) of dimethyl sulphoxide, 800 mg (1.63 mmol) of (4E)-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-2-(1-hydroxyethyl)-5-phenyl-4-pentenamide and 1.82 g (18.0 mmol) of triethylamine are reacted to give (4E)-2-acetyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]-ethyl}-5-phenyl-4-pentenamide.

Provenance & Evidence