HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-acetyl-5-cyclohexyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}pentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-Acetyl-5-cyclohexylpentanoic acid | HCID 18370812 | — |
| Reactant | 6-(1-Aminoethyl)-3-[(3,4-dimethoxyphenyl)methyl]-1,2,4-triazin-5(2H)-one | HCID 135697923 | — |
| Product | 2-acetyl-5-cyclohexyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}pentanamide | HCID 136017764 | — |
Reaction Steps
The amount of 2-acetyl-5-cyclohexylpentanoic acid in dichloromethane from Example 36A is reacted analogously to Example 39A with 280 mg (2.08 mmol) of 1-hydroxy-1H-benzotriazole, 610 mg (6.00 mmol) of 4-methylmorpholine, 400 mg (2.08 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 600 mg (2.08 mmol) of 6-(1-aminoethyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one to give 2-acetyl-5-cyclohexyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl }pentanamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06573263B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-ffa3ea4a8e0d43cf8aa8df1f12127ecd |
| Source note | uspto-grants-2003_06 |