1-Hydroxybenzotriazole → N-{1-[3-(3-ethoxy-4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}2-(1-hydroxyethyl)-5-phenylpentanamide

Participants

Reaction Steps

423 mg (1.90 mmol) of 2-(1-hydroxyethyl)-5-phenylpentanoic acid, are reacted analogously to Example 39A with 257 mg (1.90 mmol) of 1-hydroxy-1H-benzotriazole, 328 mg (2.54 mmol) of N-ethyldiisopropylamine, 365 mg (1.90 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 432 mg (1.27 mmol) of 6-(1-aminopropyl)-3-(3-ethoxy-4-methoxybenzyl)-1,2,4-triazin-5(4H)-one to give N-{1-[3-(3-ethoxy-4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}2-(1-hydroxyethyl)-5-phenylpentanamide.

Provenance & Evidence