1-Hydroxybenzotriazole → 2-(1-hydroxyethyl)-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenylpentanamide

Participants

Reaction Steps

526 mg (2.37 mmol) of 2-(1-hydroxyethyl)-5-phenylpentanoic acid are reacted analogously to Example 39A with 320 mg (2.37 mmol) of 1-hydroxy-1H-benzotriazole, 408 mg (3.16 mmol) of N-ethyldiisopropylamine, 454 mg (6.350 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 500 mg (1.58 mmol) of 6-(1-aminoethyl)-3-(1-naphthylmethyl)-1,2,4-triazin-5(4H)-one to give 2-(1-hydroxyethyl)-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenylpentanamide.

Provenance & Evidence