Dimethyl Sulfoxide → 2-acetyl-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenylpentanamide

Participants

Reaction Steps

Analogously to Example 40, 310 mg (2.44 mmol) of oxalyl chloride, 239 mg (3.05 mmol) of dimethyl sulphoxide, 740 mg (1.53 mmol) of 2-(1-hydroxyethyl)-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenyl-pentanamide and 790 mg (6.11 mmol) of N-ethyldiisopropylamine are reacted to give 2-acetyl-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenylpentanamide.

Provenance & Evidence