Sodium borohydride → HCID 135469595, compound

HRID 1368321Notes

Reaction equation

[C:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:34])[NH:19][C:20]([CH2:23][C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[N:30]=[CH:29][CH:28]=[CH:27]4)=[N:21]2)=[C:16]([CH3:35])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:34])[NH:19][C:20]([CH2:23][C:24]3[CH:25]=[C:26]4[C:31](=[CH:32][CH:33]=3)[N:30]=[CH:29][CH:28]=[CH:27]4)=[N:21]2)=[C:16]([CH3:35])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH3:2]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 135547863HCID 135547863, compound

Product 1

HCID 135469595HCID 135469595, compound

Procedure

7-(1-Acetyl-4-phenylbutyl)-2-(quinolin-6-ylmethyl)-5-methylimidazo[5,1-f][1,2,4]-triazin-4(3H)-one is reacted analogously to Example 12 with sodium borohydride to give 7-[1-(1-hydroxyethyl)-4-phenylbutyl]-2-(quinolin-6-ylmethyl)-5-methylimidazo-[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record: ord-2c07554e5b4340828a69d40b3356f935
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573263B2

Reaction notes

Loading…