Sodium borohydride → HCID 135547837, compound

HRID 1368322Notes

Reaction equation

[C:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:32])[NH:19][C:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)=[N:21]2)=[C:16]([CH3:33])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:32])[NH:19][C:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)=[N:21]2)=[C:16]([CH3:33])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH3:2]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 135532576HCID 135532576, compound

Product 1

HCID 135547837HCID 135547837, compound

Procedure

80 mg (0.19 mmol) of 7-(1-acetyl-4-phenylbutyl)-2-(4-methoxybenzyl)-5-methyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one are reacted analogously to Example 12 with 9 mg (0.19 mmol) of sodium borohydride to give 7-[1-(1-hydroxyethyl)-4-phenyl-butyl]-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record: ord-65b8e3d9db304028bc5dec6774f43aea
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573263B2

Reaction notes

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