Sodium borohydride → HCID 135466435, compound

HRID 1368324Notes

Reaction equation

C(C([C:14]1[N:22]2[C:17]([C:18](=[O:34])[NH:19][C:20](CC3C=CC(OC)=C(OC)C=3)=[N:21]2)=[C:16]([CH3:35])[N:15]=1)C/C=C/C1C=CC=CC=1)(=O)C.[BH4-].[Na+]>>[CH3:35][C:16]1[N:15]=[CH:14][N:22]2[C:17]=1[C:18](=[O:34])[NH:19][CH:20]=[N:21]2

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 135469606HCID 135469606, compound

Product 1

HCID 135466435HCID 135466435, compound

Procedure

70 mg (0.14 mmol) of 7-[(3E)-1-acetyl-4-phenyl-3-butenyl]-2-(3,4-dimethoxy-benzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one are reacted analogously to Example 12 with 5 mg (0.14 mmol) of sodium borohydride to give 2-(3,4-dimethoxybenzyl)-7-[(3E)-1-1-hydroxyethyl)-4-phenyl-3-butenyl]-5-methylimidazo-[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record: ord-6428caf7019a459989cf4d454fa9dee6
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573263B2

Reaction notes

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