Sodium borohydride → 7-[4-cyclohexyl-1-(1-hydroxyethyl)butyl]-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

HRID 1368326Notes

Reaction equation

HRID 1368326 reaction equation
[C:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:34])[NH:19][C:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH3:33])[CH:25]=3)=[N:21]2)=[C:16]([CH3:35])[N:15]=1)[CH2:5][CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[CH:8]1([CH2:7][CH2:6][CH2:5][CH:4]([C:14]2[N:22]3[C:17]([C:18](=[O:34])[NH:19][C:20]([CH2:23][C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH3:33])[CH:25]=4)=[N:21]3)=[C:16]([CH3:35])[N:15]=2)[CH:1]([OH:3])[CH3:2])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 1355478897-(1-acetyl-4-cyclohexylbutyl)-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Product 1

HCID 1358247187-[4-cyclohexyl-1-(1-hydroxyethyl)butyl]-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Procedure

60 mg (0.13 mmol) of 7-(1-acetyl-4-cyclohexylbutyl)-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one are reacted analogously to Example 12 with 15 mg (0.40 mmol) of sodium borohydride to give 7-[4-cyclohexyl-1-(1-hydroxyethyl)butyl]-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record
ord-01f89b8ac2e3402b816de32fbd94670b
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

Loading…