Sodium borohydride → HCID 136360256, compound

HRID 1368329Notes

Reaction equation

[C:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:37])[NH:19][C:20]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([CH3:36])=[C:28]([CH:35]=3)[CH2:29][S:30]([NH:33][CH3:34])(=[O:32])=[O:31])=[N:21]2)=[C:16]([CH3:38])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[OH:3][CH:1]([CH:4]([C:14]1[N:22]2[C:17]([C:18](=[O:37])[NH:19][C:20]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([CH3:36])=[C:28]([CH:35]=3)[CH2:29][S:30]([NH:33][CH3:34])(=[O:32])=[O:31])=[N:21]2)=[C:16]([CH3:38])[N:15]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH3:2]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 136360257HCID 136360257, compound

Product 1

HCID 136360256HCID 136360256, compound

Procedure

100 mg (0.19 mmol) of 5-{[7-(1-acetyl-4-phenylbutyl)-5-methyl-4-oxo-3,4-dihydro-imidazo[5,1-f][1,2,4]triazin-2-yl]methyl}-N,2-dimethylbenzylsulphonamide are reacted analogously to Example 12 with 7.2 mg (0.19 mmol) of sodium borohydride to give 5-({7-[1-(1-hydroxyethyl)-4-phenylbutyl]-5-methyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl}methyl)-N,2-dimethylbenzylsulphonamide.

Sources & evidence

ORD record: ord-b48cb9ad836a450f97c4b87f873daa18
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573263B2

Reaction notes

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