4-Methylmorpholine → HCID 86585966, compound

Participants

Reaction Conditions

Reaction Steps

To 3-(3,4-bis-trifluoromethanesulfonyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester (2 g, 3.47 mmol), diethyl phosphite (1 mL, 7.65 mmol) and 4-methyl morpholine (0.93 mL, 8.3 mmol) in MeCN (10 ml) was added Pd(PPh3)4 (167 mg, 0.15 mmol). The mixture was allowed to stirred for two days at 95° C. then diluted with saturated NH4Cl and extracted with EtOAc. The organic layer was dried over magnesium sulfate, concentrated, and chomatographed over silica gel (5% MeOH/EtOAc) to an oil (0.2 g, 37% yield). MS [M+H]+ 552 & [M+Na] 574.

Provenance & Evidence