Sulfuric acid magnesium salt (1:1) → 6-Methoxy-1-phenyl-tetralin-2-one

HRID 13684Notes

Reaction equation

S([O-])([O-])(=O)=O.[Mg+2].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15]1([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[O:19][CH:14]1[CH2:13][CH2:12]2>C1(C)C=CC=CC=1>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14](=[O:19])[CH2:13][CH2:12]2

Participants

Conditions

Temperature: 80 °C

Procedure

6.0 Grams (0.05 mols) of magnesium sulfate and 500 mL of toluene were added to 50.5 g (0.20 mols) of 5-methoxy-7b-phenyl-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a]naphthalene, and the mixture was heated at 80° C. for 2 hours. After cooled, the reaction product was washed two times each with 250 mL of water, and the organic layer was condensed under reduced pressure to obtain 6-methoxy-1-phenyl-3,4-dihydro-1H-naphthalene-2-one represented by the following formula,

Workup

temperatureAfter cooled
washthe reaction product was washed two times each with 250 mL of water
customcondensed under reduced pressure

Sources & evidence

ORD record: ord-b50bc787d5a5498e98ea09b2cc457d1c
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728154B2

Reaction notes

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