5-Bromo-2-oxindole → HCID 67280925, compound

HRID 1368412Notes

Reaction equation

HRID 1368412 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:29]=O)=[C:26]([CH3:28])[CH:27]=2)=[O:22])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:29]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])=[C:26]([CH3:28])[CH:27]=2)=[O:22])[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 9813906HCID 9813906, compound

Product 1

HCID 67280925HCID 67280925, compoundYield 17.3%

Procedure

5-Bromo-1,3-dihydroindol-2-one (0.16 g, 0.76 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (3-pyrrolidin-1-ylpropyl)amide (0.2 g, prepared by method C) to give 60 mg (17%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-87e56e2406744035af92bf16252fa7ed
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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