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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1368418Generated: October 31, 2026

Oxindole → 3-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide

https://huagongshe.com/reaction/1368418

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxindoleHCID 321710—
Reactant5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl) amideHCID 86586196—
Reactant3-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl esterHCID 86586197—
Product3-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amideHCID 6728097221%

Reaction Steps

Oxindole (66.5 mg, 0.5 mmol) was condensed with 5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl) amide (prepared from 3-formyl-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester by method B then C) to give 39 mg (21%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06573293B2
Source datasetuspto-grants-2003_06
ORD IDord-118fb172113d4ebd8e40bee99c373743
Source noteuspto-grants-2003_06