5-Bromo-2-oxindole → HCID 67282711, compound

HRID 1368424Notes

Reaction equation

HRID 1368424 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:32][CH3:33])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:30]=O)=[C:24]2[C:29]=1[CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:20])[CH3:13]>>[CH2:32]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:30]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:24]2[C:29]=1[CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:20])[CH3:33]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586199HCID 86586199, compound

Product 1

HCID 67282711HCID 67282711, compoundYield 67.3%

Procedure

5-Bromo-1,3-dihydroindol-2-one (20 mg, 0.1 mmol) was condensed with 3-formyl-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid (3-diethylaminopropyl)amide (30 mg) to give 33 mg (46%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-95bf1cd8a8864a27a0dede759e390317
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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