6-Pyridin-3-yl-1,3-dihydro-indol-2-one → HCID 67281641, compound

HRID 1368426Notes

Reaction equation

HRID 1368426 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][C:12](=[O:16])[NH:13]3)=[CH:9][CH:8]=2)[CH:2]=1.[CH2:17]([N:19]([CH2:36][CH3:37])[CH2:20][CH2:21][NH:22][C:23]([C:25]1[NH:26][C:27]([CH:34]=O)=[C:28]2[C:33]=1[CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:24])[CH3:18]>>[CH2:36]([N:19]([CH2:17][CH3:18])[CH2:20][CH2:21][NH:22][C:23]([C:25]1[NH:26][C:27]([CH:34]=[C:11]2[C:10]3[C:14](=[CH:15][C:7]([C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)=[CH:8][CH:9]=3)[NH:13][C:12]2=[O:16])=[C:28]2[C:33]=1[CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:24])[CH3:37]

Participants

3

Reactant 2

HCID 219155796-Pyridin-3-yl-1,3-dihydro-indol-2-oneHCID 86586198HCID 86586198, compound

Product 1

HCID 67281641HCID 67281641, compoundYield 38%

Procedure

6-Pyridin-3-yl-1,3-dihydroindol-2-one (60 mg, 0.4 mmol) was condensed with 3-formyl-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid (2-diethylaminoethyl)amide (80 mg) to give 50 mg (38%) of the title compound as a reddish solid.

Sources & evidence

ORD record
ord-550e346757894e49ae4928c43432ec6d
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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