5-Bromo-2-oxindole → HCID 67280776, compound

HRID 1368432Notes

Reaction equation

HRID 1368432 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:37][CH3:38])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:24]([CH:32]=O)[NH:23][C:22]=1[CH:34]([CH3:36])[CH3:35])=[O:20])[CH3:13]>>[CH2:37]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:24]([CH:32]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:23][C:22]=1[CH:34]([CH3:36])[CH3:35])=[O:20])[CH3:38]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586202HCID 86586202, compound

Product 1

HCID 67280776HCID 67280776, compoundYield 71%

Procedure

5-Bromo-1,3-dihydroindol-2-one (120 mg, 0.31 mmol) was condensed with 5-formyl-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (prepared by method C) to give 120 mg (71%) of the title compound.

Sources & evidence

ORD record
ord-3642a7af00834708a1c7a4ccef2e527b
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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