5-Bromo-2-oxindole → HCID 67281571, compound

HRID 1368434Notes

Reaction equation

HRID 1368434 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:36][CH3:37])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[C:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:23]([CH:31]=O)[NH:22][C:21]=1[CH:33]([CH3:35])[CH3:34])=[O:19])[CH3:13]>>[CH2:36]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[C:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[C:23]([CH:31]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:22][C:21]=1[CH:33]([CH3:35])[CH3:34])=[O:19])[CH3:37]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586203HCID 86586203, compound

Product 1

HCID 67281571HCID 67281571, compoundYield 53%

Procedure

5-Bromo-1,3-dihydroindol-2-one (57 μg. 0.27 mmol) was condensed with 5-formyl-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (120 mg) to give 78 mg (53%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-bf8efe13246d4cffa90d5a6b0e95459c
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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