5-Bromo-2-oxindole → HCID 67282637, compound

HRID 1368442Notes

Reaction equation

HRID 1368442 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:35][CH3:36])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:24]([CH:32]=O)[NH:23][C:22]=1[CH3:34])=[O:20])[CH3:13]>>[CH2:35]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:24]([CH:32]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:23][C:22]=1[CH3:34])=[O:20])[CH3:36]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586207HCID 86586207, compound

Product 1

HCID 67282637HCID 67282637, compoundYield 42%

Procedure

5-bromo-1,3-dihydroindol-2-one (0.47 g, 2.2 mmol) was condensed with 5-formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (0.75 g) to give 0.11 g (42%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-fdd96cc45e38417c8bbd16f40d53931a
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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